Cholesterol and Cardiovascular Risk in Type 2 Diabetes: The Role of Kidney Function.

ABSTRACT:

Objective

The association of lipid parameters with cardiovascular disease (CVD) and the impact of kidney function on this association have not been thoroughly evaluated in patients with type 2 diabetes mellitus (T2DM).

Methods

Using the Korean National Health Insurance Service Cohort database, we identified 2,343,882 subjects with T2DM in 2015-2016. Baseline lipid levels and kidney function were evaluated and followed up until December 2020. Subjects were classified into three groups according to their estimated glomerular filtration rate (eGFR): ≥60, 30-59, or <30 mL/min/1.73 m². We analyzed the diabetes group with eGFR ≥60 and low-density lipoprotein cholesterol (LDL-C) <70 mg/dL as a reference group.

Results

The risk of CVD began to increase at LDL-C ≥10

SUBMITTER: Kim JH 

PROVIDER: S-EPMC12145966 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature