Is chronic inflammation a risk factor for perioperative myocardial injury or heart failure in pancreatic surgery patients?

ABSTRACT:

Background

Chronic inflammation is associated with cardiovascular disease. Whether cardiac risk is increased in surgical patients with chronic inflammation is unknown. We hypothesised that preoperative interleukin 6 (IL-6) is associated with postoperative biomarker release indicative of myocardial injury and heart failure.

Methods

In this prospective cohort study in pancreatic surgery patients, concentrations of IL-6, high-sensitive cardiac troponin-T (hs-cTnT), growth differentiation factor 15 (GDF-15), and N-terminal pro B-type natriuretic peptide (NT-proBNP) were assessed before surgery and 4, 12, 24, and 48 h after surgery. The primary outcome was perioperative myocardial injury (PMI), defined as an absolute hs-cTnT increase ≥14 pg ml^-1. Secondary outcomes wer

SUBMITTER: Reniers T 

PROVIDER: S-EPMC12145987 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature