Treatment of Hypovitaminosis D With Cholecalciferol in Dogs With Protein-Losing Enteropathies: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial.

ABSTRACT:

Background

The effects of vitamin D supplementation are unknown in dogs with protein-losing enteropathy (PLE).

Objective

To evaluate the safety, efficacy, and clinical benefit of orally administered cholecalciferol in dogs with PLE and decreased serum concentrations of 25OHD.

Animals

Twenty-eight dogs with PLE, decreased 25OHD, and serum ionized calcium (iCa) > 1.0 mmol/L (n = 15 treated with cholecalciferol, n = 13 treated with placebo).

Methods

Prospective, double-blinded, randomized, controlled trial. Dogs randomized to receive 400 IU/kg cholecalciferol or placebo PO daily along with standard therapy for 6 weeks. Clinical and biochemical variables were measured at baseline (T0) and monitored at 2 (T1), 4 (T2), and 6 (T3) weeks postmedication initiation. Clin

SUBMITTER: Jablonski SA 

PROVIDER: S-EPMC12146210 | biostudies-literature | 2025 Jul-Aug

REPOSITORIES: biostudies-literature