Ageing Signatures and Disturbed Muscle Regeneration in Muscle Proteome of Inclusion Body Myositis.

ABSTRACT:

Background

Inclusion body myositis (IBM) is the most common acquired myopathy in adults over the age of 50 years, characterised by inflammatory and degenerative features that lead to progressive muscle weakness and physical disability for lack of effective therapies. The complex interplay between inflammatory and degenerative processes, occurring seemingly simultaneously, presents a challenge to systematically dissect disease pathology and discover novel therapeutic targets.

Methods

To identify proteomic IBM disease signatures and upstream regulators of disease processes in an unbiased manner, we performed high-resolution iTRAQ-labelled mass spectrometry on whole muscle lysates of 28 IBM patients and 28 control individuals. Validation experiments were carried out by conducti

SUBMITTER: de Vries GM 

PROVIDER: S-EPMC12146582 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature