Genetic Inactivation of the Serotonin Transporter Dysregulates Expression of Neurotransmission Genes and Genome-Wide DNA Methylation Levels in the Medial Prefrontal Cortex of Male Rats During Postnatal Development.

ABSTRACT: Reduced expression of the serotonin transporter (5-hydroxytryptamine transporter, 5-HTT) in early life has been associated with a delay in postnatal brain development and endophenotypes of a variety of neuropsychiatric and neurodevelopmental disorders in adolescence and adulthood. How a reduction in functional 5-HTT can disrupt neurodevelopment is still largely unknown. Here, we studied genome-wide gene expression using transcriptome analysis (RNA-seq) and global levels of DNA (hydroxy)methylation (5(h)mC) using high-performance liquid chromatography-tandem mass spectrometry in 5-HTT wild-type (5-HTT^+/+) and 5-HTT homozygous knockout (5-HTT^-/-) rats across life (postnatal day [PND] 8, 14, 21, 35, and 70) in the medial prefrontal cortex (mPFC); a brain region with an e

SUBMITTER: Kroeze Y 

PROVIDER: S-EPMC12146603 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature