Second generation CD2-targeting LFA-3 fusion protein SBT115301 to restore immune homeostasis in autoimmune disease.

ABSTRACT: In autoimmunity, an imbalance of effector (T_eff) and regulatory (T_reg)T cells contributes to inflammation and tissue destruction. CD2, highly expressed on T_eff and at lower levels on T_reg and naive T cells (T_n), is an attractive target for depleting T_eff at sites of inflammation. SBT115301 is a second generation CD2-targeting fusion protein containing the cognate receptor of CD2, lymphocyte function associated antigen-3 (LFA-3; CD58). In in vitro and in vivo studies, SBT115301 preferentially decreased CD2^hi-expressing T_eff cells compared to T_reg and T_n. In a phase 1 clinical trial, SBT115301 selectively reduced memory T cells. SBT115301 was well tolerated aside from d

SUBMITTER: Lebrec H 

PROVIDER: S-EPMC12146614 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature