Allelic variations and gene cluster modularity act as nonlinear bottlenecks for cholera emergence.

ABSTRACT: The underlying factors that lead to specific strains within a species to emerge as human pathogens remain mostly enigmatic. The diarrheal disease cholera is caused by strains from a phylogenetically confined group within the Vibrio cholerae species, the pandemic cholera group (PCG), making it an ideal model system to tackle this puzzling phenomenon. Comprehensive analyses of over 1,840 V. cholerae genomes, including environmental isolates from this study, reveal that the species consists of eleven groups, with the PCG belonging to the largest and located within a lineage shared with environmental strains. This hierarchical classification provided us with a framework to unravel the ecoevolutionary dynamics of the genetic determinants associated with the emergence of toxigenic

SUBMITTER: Lopez-Perez M 

PROVIDER: S-EPMC12146696 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature