Regulation of carcinogenesis through multiple zinc fingers in ZBTB20.

ABSTRACT: Zinc finger (ZF) proteins regulate transcription by interacting with cis-acting elements for gene expression in response to stimuli within physiological systems. Bioinformatic studies have proposed that zinc finger and BTB (Broad complex, Tramtrack, Bric-à-brac) domain-containing protein 20 (ZBTB20) acts as a key regulator of crucial genes associated with carcinogenesis. However, biochemical experiments using purified proteins remain unreported. In this study, we investigated the regulatory functions of the ZF domains in ZBTB20, which has five CX₂CX₁₂HX₃H-type classical ZF domains, in the inhibition and expression of downstream transcription factors, including alpha-fetoprotein (AFP) and forkhead box transcription factor O1 (FOXO1). The four ZF domai

SUBMITTER: Kim H 

PROVIDER: S-EPMC12146892 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature