Associations between fatigue and cellular metabolism in breast cancer patients: A longitudinal study.

ABSTRACT:

Purpose

Fatigue is frequently experienced during treatment for cancer and persists for months to years after treatment completion in a subset of patients. The underlying mechanisms remain poorly understood. We postulated that reduced cellular energy metabolism may underlie fatigue in cancer patients and survivors and tested this hypothesis in a sample of patients newly diagnosed with early-stage breast cancer (n = 49) followed for approximately 1 year from before the start of neoadjuvant chemotherapy (NACT) till after treatment completion.

Methods

Patient-reported fatigue was assessed with the Checklist Individual Strength, and blood samples were obtained before, during, and shortly after NACT. A final assessment was completed after surgery and radiation therapy, 4-6 months

SUBMITTER: Lacourt TE 

PROVIDER: S-EPMC12147089 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature