Convergent and divergent transcriptional reprogramming of motor and sensory neurons underlying response to peripheral nerve injury.

ABSTRACT:

Introduction

Motor neurons differ from sensory neurons in aspects including origins and surrounding environment. Understanding the similarities and differences in molecular response to peripheral nerve injury (PNI) and regeneration between sensory and motor neurons is crucial for developing effective drug targets for CNS regeneration. However, genome-wide comparisons of molecular changes between sensory and motor neurons following PNI remains limited.

Objectives

This study aims to investigate genome-wide convergence and divergence of injury response between sensory and motor neurons to identify novel drug targets for neural repair.

Methods

We analyzed two large-scale RNA-seq datasets of in situ captured sensory neurons (SNs) and motoneurons (MNs) upon PNI, retinal gan

SUBMITTER: Yang J 

PROVIDER: S-EPMC12147598 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature