NDRG1 enhances the sensitivity to Cetuximab by promoting Stat1 ubiquitylation in colorectal cancer.

ABSTRACT:

Introduction

Cetuximab (CTX) is an effective targeted drug for the treatment of metastatic colorectal cancer, but it is effective only in patients with wild-type KRAS genes. Even in this subset of patients, the sensitivity of CTX in patients with right hemi-colon cancer is much lower than that in patients with left hemi-colon cancer. This significantly limits its clinical application. Therefore, further elucidation of the underlying molecular mechanisms is needed. N-myc downstream-regulated gene 1 (NDRG1) plays an important role in solid tumor invasion and metastasis, but whether it can influence CTX sensitivity has not been thoroughly investigated.

Objective

Our study aimed to identify a novel mechanism by which NDRG1 affects CTX sensitivity.

Methods

Through mass spe

SUBMITTER: Yang G 

PROVIDER: S-EPMC12147639 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature