Predictive ability of the Cancer and Aging Research Group chemotherapy toxicity calculator in hematologic malignancy.

ABSTRACT:

Introduction

Chemotherapy toxicity tools are rarely studied in patients with hematologic malignancy (HM). The primary aim of this pilot study was to determine the predictive ability of the Cancer and Aging Research Group (CARG) chemo-toxicity calculator in estimating grade 3-5 toxicity in patients with HM.

Materials and methods

Patients 60 years and older with HM were prospectively evaluated using the CARG chemo-toxicity calculator. Discrimination and calibration were checked by applying the published model in our data. Additionally, a full geriatric assessment (GA), the Short Physical Performance Battery (SPPB), and health related quality of life (HRQoL) were captured longitudinally at the start of treatment and at end of study. Secondary aims explored the association of GA

SUBMITTER: Rosko AE 

PROVIDER: S-EPMC12147674 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature