The diverging role of O-GlcNAc transferase in corticotroph and somatotroph adenomas.

ABSTRACT:

Purpose

Molecular mechanisms involved in the pathogenesis and tumor progression of pituitary adenomas (PA) remain incompletely understood. Corticotroph and somatotroph PA are associated with a high clinical burden, and despite improved surgical outcomes and medical treatment options, they sometimes require multiple surgeries and radiation. Preliminary data suggested a role for O-GlcNAc Transferase (OGT), the enzyme responsible for the O-GlcNAcylation of proteins. O-GlcNAcylation and OGT have been found elevated in other types of tumors.

Methods

We evaluated 60 functioning and nonfunctioning PA (NFPA) from operated patients and postmortem normal and tumoral pituitary tissue by immunohistochemistry. We performed transcriptomic analyses to explore the relevance of the O-GlcNAc

SUBMITTER: Gonzalez R 

PROVIDER: S-EPMC12147819 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature