Myeloperoxidase impacts vascular function by altering perivascular adipocytes' secretome and phenotype in obesity.

ABSTRACT: Obesity, a main driver of cardiovascular morbidity, contributes to endothelial dysfunction and inflammation in adipose tissues. Perivascular adipose tissue (PVAT) surrounds arteries and influences vascular function. In obesity, immune cells, including myeloperoxidase (MPO)-releasing myeloid cells, accumulate in PVAT. In this study, we show MPO levels to correlate with body weight and endothelial function in obese patients (n = 33) and mice. In addition, MPO deficiency reduces immune cell frequency, enhances PVAT beiging via soluble guanylyl cyclase β1 (sGC-β1), and increases oxygen consumption in vivo. Further, nitrotyrosine formation and inflammatory cytokine release are attenuated in obese Mpo^-/- mice. Mechanistically, adiponectin (APN) secretion improves endothelial function

SUBMITTER: Hof A 

PROVIDER: S-EPMC12147848 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature