MMRNet: Ensemble deep learning models for predicting mismatch repair deficiency in endometrial cancer from histopathological images.

ABSTRACT: Combining molecular classification with clinicopathologic methods improves risk assessment and chooses therapies for endometrial cancer (EC). Detecting mismatch repair (MMR) deficiencies in EC is crucial for screening Lynch syndrome and identifying immunotherapy candidates. An affordable and accessible tool is urgently needed to determine MMR status in EC patients. We introduce MMRNet, a deep convolutional neural network designed to predict MMR-deficient EC from whole-slide images stained with hematoxylin and eosin. MMRNet demonstrates strong performance, achieving an average area under the receiver operating characteristic curve (AUROC) of 0.897, with a sensitivity of 0.628 and a specificity of 0.949 in internal cross-validation. External validation using three additional datasets results

SUBMITTER: Liu LL 

PROVIDER: S-EPMC12147852 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature