Dysfunctional one-carbon metabolism identifies vitamins B₆, B₉, B₁₂, and choline as neuroprotective in glaucoma.

ABSTRACT: Glaucoma, characterized by the loss of retinal ganglion cells (RGCs), is a leading cause of blindness for which there are no neuroprotective therapies. To explore observations of elevated homocysteine in glaucoma, we elevate vitreous homocysteine, which increases RGC death by 6% following ocular hypertension. Genetic association with higher homocysteine does not affect glaucoma-associated outcomes from the UK Biobank and serum homocysteine levels have no effect on glaucomatous visual field progression. This supports a hypothesis in which elevated homocysteine is a pathogenic, rather than causative, feature of glaucoma. Further exploration of homocysteine metabolism in glaucoma animal models demonstrates early and sustained dysregulation of genes involved in one-carbon metabolism and the in

SUBMITTER: Tribble JR 

PROVIDER: S-EPMC12147907 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature