ScRNA-seq reveals an immune microenvironment and JUN-mediated NK cell exhaustion in relapsed T-ALL.

ABSTRACT: T cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous disease characterized by a high relapse rate. By single-cell transcriptome analysis, we characterize the bone marrow immune microenvironment in patients with T-ALL, identifying 13 major cell clusters. These patients exhibited abnormally expanded hematopoietic stem cells (HSCs) and granulocyte-monocyte progenitors (GMPs), immunosuppressive traits in CD4⁺ T, CD8⁺ T, and natural killer (NK) cells. Subdividing CD4⁺ T cells reveal two subsets transitioning between T helper (Th)1/Th2, Annexin-A1 (ANXA1)^-GATA3^-CD4⁺ T, and ANXA1⁺GATA3⁺CD4⁺ T. Additionally, NK cells demonstrate exhaustion in the tumor microenvironment of patients with rela

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12147915 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature