Albumin is ubiquitously expressed in the dolphin body and upregulated by an extracellular albumin shortage.

ABSTRACT: This study demonstrates that hepatocyte-specific albumin is ubiquitously expressed and the protein is produced in both common bottlenose dolphins Tursiops truncatus and striped dolphins Stenella coeruleoalba. Quantitative PCR revealed that albumin precursor mRNA is expressed in all 12 tissues examined, with the highest levels observed in the liver. Next, TA cloning using skin and liver of the two species confirmed that the deduced albumin animo acid sequences in the tissues are 100% identical within each species and slightly different between the species or between tissues in common bottlenose dolphin and cultured cells derived from the same species. In addition, western blot analysis showed positive bands of approximately 66 kDa in all tissues examined, as seen with serum albumin. Immunoh

SUBMITTER: Saito K 

PROVIDER: S-EPMC12148036 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature