Aldo-keto reductase family 1 member C3 (AKR1C3) gene polymorphism (rs12529) is associated with breast cancer in Bangladeshi population: A case-control study and computational investigation.

ABSTRACT: Breast cancer is defined as the unchecked growth of breast cells, with imbalances in prostaglandin and steroid hormone metabolism contributing to disease risk by altering prostaglandin types and forms (strong and weak) of steroid hormones. The AKR1C3 enzyme plays a key role in managing these metabolic processes. This study investigated the association between the AKR1C3 gene polymorphism (rs12529) and the risk of developing breast cancer in Bangladeshi individuals. A case-control investigation was conducted with a total of 620 samples, involving 310 individuals diagnosed with breast cancer and 310 healthy subjects. Herein, DNA extraction was performed via an organic process, whereas genotyping was employed via the PCR‒RFLP technique. Statistical assessments were conducted to analyze the as

SUBMITTER: Shaon MA 

PROVIDER: S-EPMC12148162 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature