Potassium homeostasis during disease progression of Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is an age-dependent neurodegenerative disorder characterized by neuronal loss leading to dementia and ultimately death. Whilst the loss of neurons is central to this disease, it is becoming clear that glia, specifically astrocytes, contribute to the onset and progression of neurodegeneration. The role of astrocytes in maintaining ion homeostasis in the extracellular milieu is fundamental for multiple brain functions, including synaptic plasticity and neuronal excitability, which are compromised during AD and affect neuronal signalling. In this study, we measured the astrocytic K⁺ clearance rate in the hippocampus and somatosensory cortex of a mouse model for AD during disease progression. Our results establish that astrocytic [K⁺]_o

SUBMITTER: Samokhina E 

PROVIDER: S-EPMC12148202 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature