An individualized tractography pipeline for the nucleus basalis of Meynert lateral tract.

ABSTRACT:

Background

At the center of the cortical cholinergic network, the nucleus basalis of Meynert (NBM) is crucial for the cognitive domains most vulnerable in Parkinson's disease (PD). Preclinical evidence has demonstrated the positive impact of NBM deep brain stimulation (DBS) on cognition but early human trials have had mixed results. It is possible that DBS of the lateral NBM efferent white matter fiber bundle may be more effective at improving cognitive-motor function. However, precise tractography modelling is required to identify the optimal target for neurosurgical planning. Individualized tractography approaches have been shown to be highly effective for accurately identifying DBS targets but have yet to be developed for the NBM.

Methods

Using structural and diffusion-we

SUBMITTER: Crockett RA 

PROVIDER: S-EPMC12148219 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature