Prospective Genomic Surveillance of Severe Febrile Illness in Tanzanian Children Identifies High Mortality and Resistance to First-Line Antibiotics in Bloodstream Infections.

ABSTRACT: We evaluated the prevalence, pathogen profile, and antimicrobial resistance (AMR) patterns of bloodstream infections (BSIs) among 392 children with severe febrile illness who presented (July 26, 2022-September 20, 2023) to a referral hospital in Tanzania. We identified a causative pathogen in 9.8% (n=38) of participants. Blood culture analysis confirmed BSI in 5.2% (n=20) of participants with a case fatality rate of 45%. Whole genome sequencing (WGS) of blood culture isolates identified gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae) as the predominant pathogens, many exhibiting extended-spectrum beta-lactamase (ESBL) resistance genes (CTX-M-15, CTX-M-27), rendering them resistant to first-line antimicrobials. We also observed probable nosocomial transmission in ven

SUBMITTER: Kortz TB 

PROVIDER: S-EPMC12148265 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature