Prognostic Significance of CD8 T-cell Spatial Biomarkers in ER+ and ER- Breast Cancer.

ABSTRACT: Tumor Infiltrating Lymphocytes (TILs) have been shown to be prognostic in Triple-Negative Breast Cancer (TNBC), but are rarely considered in other subtypes, particularly estrogen receptor (ER) positive cancers (70-80% of breast cancers), due to lower TIL counts. However, the spatial proximity of lower abundance TILs has not been evaluated in relation to breast cancer prognosis. In this study, multiplex immunofluorescent-stained images were used to identify cell types based on cytokeratin (Ck), CD8, and FoxP3 expression. Using distance-based visual morphometry between epithelial and immune cells, we computed new metrics, proximity and consistency, which capture spatial relationships between Ck+ tumor cells and CD8+ T-cells. Prognostic significance of proximity and consistency

SUBMITTER: Walker AE 

PROVIDER: S-EPMC12148275 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature