The rise and global spread of IMP carbapenemases (1996-2023): a genomic epidemiology study.

ABSTRACT:

Background

IMP carbapenemases confer extensive drug resistance and are increasingly noted worldwide. Despite this, little is known regarding the global epidemiology of IMP carbapenemases.

Methods

We comprehensively identified bla _IMP genes in all publicly available bacterial genomes, then systematically analysed the distribution of variants across species, lineages, plasmids and mobile elements, examining patterns over time, across geographic regions and by source. Structural analysis of IMP variants was performed.

Findings

4,556 bla _IMP-containing genomes were identified from 1996-2023, including 52 bla _IMP variants across 93 bacterial species. Key variants (bla _IMP-1, bla _IMP-4

SUBMITTER: Vezina B 

PROVIDER: S-EPMC12148276 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature