Genetic and environmental effects on weight gain from young adulthood to old age and its association with body mass index at early young adulthood: an individual-based pooled analysis of 16 twin cohorts.

ABSTRACT:

Introduction

Genetic factors contribute to weight gain, but how these effects change over adulthood is still unknown. We studied the impact of genetics on BMI change from young adulthood to old age and its relationship with BMI in early young adulthood.

Data and methods

Data from 16 longitudinal twin cohorts, including 111,370 adults (56% women) and 55,657 complete twin pairs (42% monozygotic), were pooled. The data were divided into three stages (young adulthood-early middle age, late middle age, and old age). BMI change was calculated using linear mixed effects and delta slope methods. Genetic and environmental contributions to these changes and their correlations with baseline BMI were estimated through structural equation modeling.

Results

The average BMI increase

SUBMITTER: Obeso A 

PROVIDER: S-EPMC12148285 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature