A case-cohort longitudinal study for the analysis of microbial associations and viruses on the risk of celiac disease (MAVRiC).

ABSTRACT: Celiac disease etiopathogenesis requires genetic predisposition and exposure to gluten before a child can develop the chronic autoimmune disorder. However, these factors alone are not sufficient. Even a child with persistent tissue transglutaminase autoantibodies (tTGA), i.e., celiac disease autoimmunity (CDA), does not necessarily develop celiac disease. Larger longitudinal studies are needed to determine the impact of time-varying infections and gut microorganisms on the subsequent and specific risk of celiac disease. The aim was to design a celiac disease case-cohort longitudinal study using The Environmental Determinants of Diabetes in the Young (TEDDY) study. Following the TEDDY cohort up age 3-years, CDA was confirmed in 704 of the 6132 genetically at-risk children. Celiac disease on

SUBMITTER: Lynch KF 

PROVIDER: S-EPMC12148286 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature