The Concept of "Converse Therapeutic Hierarchy" for Patients with Hepatocellular Carcinoma.

ABSTRACT:

Background

The clinical complexity of patients with hepatocellular carcinoma (HCC), the availability of multiple therapeutic options, and clinical therapeutic intents could make it challenging to identify an unequivocal limit between conversion, downstaging/downsizing, and neoadjuvant therapies and curative or palliative intent treatments and to dimension the most proper sequential therapeutic strategy for each patient.

Summary

The concept of converse therapeutic hierarchy could rationally embrace all the different sequential treatment options (e.g., from surgery to systemic therapy) and the different therapeutic clinical intents (e.g., curative, neoadjuvant, downstaging/downsizing, conversion, and palliative), sharing the common goal of converting the patient with HCC from

SUBMITTER: Vitale A 

PROVIDER: S-EPMC12148337 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature