Catalyzing early ovarian cancer detection: Platelet RNA-based precision screening.

ABSTRACT: Early detection of ovarian cancer is crucial for successful treatment, yet most cases are diagnosed at advanced stages due to a lack of effective screening. Recent advancements in RNA technology from platelets aid in early tumor detection. Here, we proposed our two-step method for assessing the existence of pelvic mass either located at ovaries or uterus with more than 99% specificity by utilizing exon-exon junction features with a sampling invariant normalization technique; then next our model finds the malignancy of detected mass with more than 99% negative predictive value for ovarian cancer to practically assist clinicians' further investigation via combined features of exon-exon junctions, and hematology parameters. We diverged from traditional methods by employing intron-spanning rea

SUBMITTER: Ahn E 

PROVIDER: S-EPMC12148375 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature