<i>Grin2a</i> Hypofunction Impairs Spatial Working Memory and Disrupts Hippocampal Network Oscillations and Excitatory-Inhibitory Balance.

ABSTRACT:

Background

NMDA receptors, particularly those containing the GluN2A subunit, are critical for hippocampal-dependent learning and memory. The GluN2A subunit is encoded by the GRIN2A gene and is essential for maintaining cognitive function, including working memory. In this study, we explored how full or partial ablation of the mouse Grin2a gene impairs working memory and disrupts hippocampal network oscillations and excitatory/inhibitory (E/I) balance.

Methods

Male Grin2a mutant mice were assessed for spatial working memory deficits using the 8-arm radial maze. We utilized multielectrode arrays and whole-cell patch-clamp electrophysiology to evaluate network oscillations and synaptic inputs to pyramidal cells in ex vivo hippocampal slices. We performed an

SUBMITTER: Hosseini H 

PROVIDER: S-EPMC12148582 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature