Modelling adrenal steroid profiles to inform monitoring guidance in congenital adrenal hyperplasia.

ABSTRACT:

Background

There is no consensus on how to monitor adrenal androgens in Congenital Adrenal Hyperplasia (CAH).

Methods

Modelling of serum and salivary steroid profiles in healthy participants and patients with CAH randomised to either standard treatment or modified-release hydrocortisone hard capsules (MRHC).

Findings

Changes in serum 17-hydroxyprogesterone (17OHP) and androstenedione (A4) paralleled each other in healthy participants (n = 19) and patients with CAH (n = 122). However, healthy participants had similar absolute levels of 17OHP and A4 whereas patients with CAH had proportionally higher levels of 17OHP. Cross-correlation showed no lag between serum 17OHP and A4. In CAH, Bayesian multiple change point analysis converged on a 17OHP of 4.5 nmol/l below which

SUBMITTER: Lawrence NR 

PROVIDER: S-EPMC12148605 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature