Stereotactic radiosurgery for multiple small brain metastases using gamma knife versus single-isocenter VMAT: Normal brain dose based on lesion number and size.

ABSTRACT:

Purpose

The study evaluates rapid linear accelerator (Linac) single isocenter stereotactic radiosurgery (SRS) with Hyperarc for large target numbers. We compared to Gamma Knife (GK), which suffers from long treatment times and investigated causes of differences.

Methods

Linac SRS and GK treatment plans for patients receiving 18 Gy to the gross tumor volume (GTV) were evaluated for mean brain dose and volume of brain receiving 12 Gy or more (V12 Gy) as toxicity correlates. Further investigations included patient-based and simulations of 1-33 brain metastases to compare the ability of Linac SRS and GK to separate adjacent and distant lesions.

Results

For three patients (33, 33, and 18 metastases), GK reduced mean brain dose (2.89 Gy, 2.38 Gy, 2.79 Gy) compared to 2.5 mm

SUBMITTER: Abdou A 

PROVIDER: S-EPMC12148777 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature