Hepatocytes derived from human induced pluripotent stem cells: Towards establishing an <i>in vitro</i> model for assessing population variability in hepatotoxicity testing.

ABSTRACT: Interindividual differences in response to chemicals have been typically addressed through the use of a 10-fold default "uncertainty" factor. It was only recently that in vitro models emerged to quantitatively assess interindividual variability in the human population for specific chemicals. In the current study, we attempted to establish an in vitro model for assessing population variability in hepatotoxicity testing using a panel of hepatocytes derived from nine human induced pluripotent stem cell (iPSC) lines belonging to three different ethnic groups, Black or African American, Latino or Hispanic, and Non-Hispanic White. We demonstrated that the panel of iPSC-derived hepatocytes manifested diversity in hepatic function assays, in global and hepatic gene expressions, and i

SUBMITTER: Gao X 

PROVIDER: S-EPMC12148824 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature