Identification and validation of prognostic genes associated with T-cell exhaustion and macrophage polarization in breast cancer.

ABSTRACT:

Background

The most frequent malignant tumor in women is breast cancer (BRCA). It has been discovered that T-cell exhaustion and macrophages play significant roles in BRCA. It was necessary to explore prognostic genes associated with T-cell exhaustion and macrophage polarization in BRCA.

Methods

The following data were included: 35 macrophage polarization-related genes (MPRGs), 683 T-cell exhaustion-related genes (TEXRGs), GSE20685, as well as TCGA-BRCA. Initially, candidate genes were identified through crossing differentially expressed genes (DEGs) obtained by differential expression analysis, key module genes associated with MPRGs, as well as TEXRGs. Next, 101 combinations of 10 machine learning algorithms and univariate Cox analysis were utilized to screen for prognostic

SUBMITTER: Cui F 

PROVIDER: S-EPMC12148895 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature