Association Between Hormonal Factors and Risk of Lung and Upper Aerodigestive Tract Cancer in French Women: The E3N Prospective Cohort Study.

ABSTRACT:

Background

Significant sex disparities exist in the incidence of lung and upper aero-digestive tract (UADT) cancers. Inverse relationships have often been observed between exposure to hormonal factors and these cancers. Data from epidemiological studies are still inconsistent.

Aims

We investigated the association between hormonal factors and the risk of cancers of the lung and UADT in French women.

Methods

E3N is a French prospective population-based cohort that recruited 98 995 women in 1990. We used a Cox proportional hazards regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with age as the time scale. We also conducted a cluster analysis using the K-means method to assess distinct patterns of hormone exposure and the cancer risk a

SUBMITTER: Klu YE 

PROVIDER: S-EPMC12148956 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature