Dynamics understanding of novel solvated drug molecules against emerging <i>Burkholderia Cepacia</i> infections in immunocompromised patients.

ABSTRACT: The Burkholderia cepacia is a Gram-negative bacterium associated with serious infections, especially in immune compromised patients. Recent studies have shown B. cepacia to be involved in bloodstream infection in oncology patients. As the bacterium develops resistance to several classes of antibiotics and due to the depleting efficacy of current antibiotics, serious efforts are required to identify new drug targets and unveil novel chemical scaffolds against them. The bacterial tyrosine kinase enzyme takes part in exopolysaccharides production to form a biofilm matrix layer and thus results in the promotion of aggressive and resistant infections. Also, the enzyme has no close homologous copy in the human host, which warrants its targeting by novel anti-virulent compounds. In

SUBMITTER: Ahmad S 

PROVIDER: S-EPMC12149026 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature