Endogenous SLPI contributes to the regulation of inflammatory responses in peritoneal macrophages by modulating MMP-9 production.

ABSTRACT: Secretory leukocyte protease inhibitor (SLPI) is described as a potent regulator of inflammation and tissue homeostasis with pleiotropic functions. It has been shown to inhibit pro-inflammatory responses in myeloid cells. However, its expression patterns and specific functions in different monocyte and macrophage populations remain poorly understood. Therefore, we investigated its expression patterns in murine tissue macrophage populations by analysis of publicly available datasets and flow cytometry. Among various tissues, peritoneal macrophages were identified as a major source of SLPI, suggesting the highest impact of this inhibitor on their physiological and pathophysiological functions. To elucidate the role of SLPI in the inflammatory response, SLPI-deficient mice were used. First, t

SUBMITTER: Tyshchenko M 

PROVIDER: S-EPMC12149117 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature