Periodontitis aggravates pulmonary fibrosis by <i>Porphyromonas gingivalis</i>-promoted infiltration of neutrophils and Th17 cells.

ABSTRACT:

Introduction

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. However, the pathogeny of IPF is poorly understood, and therapeutic options are very limited. Periodontitis (PD) is a chronic inflammatory disease that leads to dysbiosis of both the oral microbiome and host immune responses. While previous studies have suggested a PD-IPF association, insights into the mechanisms remain limited.

Methods

The PD mouse model was established by the ligation of molars and oral inoculation of subgingival plaques from PD patients and subsequently incorporated with a bleomycin-induced pulmonary fibrosis model. The effect of PD on pulmonary fibrosis was determined. Changes of immune cells were analysed using flow cytometry. Moreover, the microbiome changes of the l

SUBMITTER: Ye HL 

PROVIDER: S-EPMC12149129 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature