Isoliensinine exerts antitumor effects in lung adenocarcinoma by inhibiting APEX1-driven ROS production.

ABSTRACT:

Introduction

Lung cancer is considered to be the world's leading malignancy in morbidity and mortality, and despite great efforts to treat it no effective treatment has yet been found. Isoliensinine is a natural small-molecule drug with potent anti-tumor activity in several cancer cell lines. Here, we have shown that Isoliensinine exhibits anti-tumor activity against lung adenocarcinoma (LUAD) both in vitro and in vivo.

Methods

The biological functions of Isoliensinine in LUAD cells were investigated using CCK8 assay, colony formation, transwell assays and flow cytometry assays. DARTS assay was used to validate Isoliensinine targets screened by site prediction and molecular docking. The in vivo anti-tumor efficacy of Isoliensinine was analyzed in the xen

SUBMITTER: Chen C 

PROVIDER: S-EPMC12149194 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature