Temporal progression of pathological features in an α-synuclein overexpression model of Parkinson's disease.

ABSTRACT: Parkinson's disease (PD) is a common neurodegenerative disorder, affecting 1-5% of individuals over 60, with a higher incidence in men. It is clinically characterized by progressive motor impairments, including rigidity, bradykinesia, tremors, and gait disturbances. The neuropathological hallmark of PD is the aggregation of α-synuclein (α-syn) into Lewy bodies (LB) and neurites (LN). Although α-syn plays essential physiological roles, its misfolding and accumulation drive neurodegeneration. In this study, we investigated the temporal progression and anatomical distribution of α-syn pathology using a bilateral adeno-associated virus serotype-9 (AAV9)-mediated α-syn overexpression model in rats. Disease-related features were analyzed at one, two and four months post-injection. Neuronal α-syn

SUBMITTER: Vaquero-Rodriguez A 

PROVIDER: S-EPMC12149260 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature