The multifaceted biomimetic titanium implant promotes bone integration with sequential antibacterial and immune modulation properties.

ABSTRACT: Titanium (Ti) and its alloy implants often face issues such as insufficient tissue adhesion and vulnerability of the bio inert surface. Given that the long-term stability of implants depends on their perfect integration with the surrounding tissues to withstand various environmental stresses, current research mainly focuses on mimicking the structure of the extracellular matrix. The aim is to promote bone tissue formation through regulation of the immune response by metal ions, thereby enhancing the effectiveness of tissue integration. The self-assembled zinc (Zn)-doped hydroxyapatite nanoparticles (nHA) with polydopamine (PDA) and copper ions (Cu²⁺) was deposited onto the alkali treated Ti surface to fabricate the P-Zn-Cu/Ti coating. The so-constructed multifunctional coating w

SUBMITTER: Chen L 

PROVIDER: S-EPMC12149584 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature