Genome-wide association studies on longitudinal phenotypes reveal genetic mechanisms of egg production in chickens.

ABSTRACT: Understanding the genetic mechanisms underlying egg production is crucial for improving laying performance in chickens. However, traditional genome-wide association studies (GWAS) have not effectively utilized the information regarding the longitudinal trajectories and dynamics of egg-laying phenotype. In this study, based on individual egg production records over time, we first utilized the Yang-Ning model to characterize four egg production parameters. Our SNP-based GWAS on these parameters, along with three multidimensional GWAS models, captured different aspects of egg-laying dynamics. The novel significant associations and candidate genes identified, including C3, CADPS2, and TLN2, contribute significantly to egg-laying traits. By quantifying both direct and indirect effects of egg pr

SUBMITTER: Tan L 

PROVIDER: S-EPMC12149598 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature