Alpha-2-Macroglobulin Attenuates Posttraumatic Osteoarthritis Cartilage Damage by Inhibiting Inflammatory Pathways With Modified Intra-articular Drilling in a Yucatan Minipig Model.

ABSTRACT:

Background

Posttraumatic osteoarthritis (PTOA) arises secondarily to joint trauma and is driven by catabolic inflammatory pathways. Alpha-2-macroglobulin (α₂M) is a naturally occurring proteinase inhibitor found in human serum and synovial fluid that binds proteases as well as proinflammatory cytokines involved in the pathogenesis of PTOA.

Purpose

(1) To investigate the therapeutic potential of intra-articular α₂M injections during the acute stages of PTOA by inhibiting inflammatory pathways driven by the cytokines expressed by the synovium in a large preclinical Yucatan minipig model and (2) to determine if 3 intra-articular α₂M injections have greater chondroprotective effects compared with 1 intra-articular injection.

Study design

C

SUBMITTER: Sun C 

PROVIDER: S-EPMC12150019 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature