Tetraspanin7 in adipose tissue remodeling and its impact on metabolic health.

ABSTRACT:

Objective

We previously identified tetraspanin 7 (Tspan7) as a candidate gene influencing body weight in an obesity-related gene screening study. However, the mechanisms underlying its involvement in body weight regulation remained unclear. This study aims to investigate the role of TSPAN7 from a metabolic perspective.

Methods

We utilized genetically modified mice, including adipose tissue-specific Tspan7-knockout and Tspan7-overexpressing models, as well as human adipose-derived stem cells with TSPAN7 knockdown and overexpression. Morphological, molecular, and omics analyses, including proteomics and transcriptomics, were performed to investigate TSPAN7 function. Physiological effects were assessed by measuring blood markers associated with lipid regulation under metabolic

SUBMITTER: Nemoto S 

PROVIDER: S-EPMC12150174 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature