Active Travel Mode and Incident Dementia and Brain Structure.

ABSTRACT:

Importance

Active travel modes, such as walking and cycling, are feasible and readily embraced forms of physical activity, but their association with dementia risk and brain structure remains unclear.

Objectives

To investigate the long-term association between travel modes and dementia risk and brain structural metrics and to evaluate whether genetic predisposition could modify the association between travel modes and dementia risk.

Design, setting, and participants

This prospective cohort study included data collected from the UK Biobank from March 13, 2006, to October 1, 2010. Data were analyzed from March to October 2024.

Exposures

Travel modes assessed using the question "In the last 4 weeks, which forms of transport have you used most often to get about (n

SUBMITTER: Hou C 

PROVIDER: S-EPMC12150188 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature