Intrapartum Sildenafil to Improve Perinatal Outcomes: A Randomized Clinical Trial.

ABSTRACT:

Importance

Sildenafil citrate may increase uteroplacental blood flow. Its ability to reduce perinatal complications related to fetal hypoxia during labor is uncertain.

Objective

To compare the effectiveness of intrapartum maternal oral sildenafil citrate vs placebo in improving perinatal outcomes potentially related to intrapartum hypoxia in term pregnancies.

Design, setting, and participants

This pragmatic, multicenter, investigator-initiated, placebo-controlled randomized clinical trial including 3257 women was conducted in 13 Australian hospitals from September 6, 2021, to June 28, 2024. The last date of follow-up (28-day neonatal mortality) was July 26, 2024. Women aged 18 years or older with singleton or dichorionic twin pregnancies, planning vaginal birth at ter

SUBMITTER: Kumar S 

PROVIDER: S-EPMC12150225 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature