Novel Metronidazole Conjugates as Antimicrobial Agents.

ABSTRACT: Metronidazole (MTZ) is one of the oldest and still used anti-infective nitroimidazole group drug. Although it is effective against anaerobic bacteria, protozoa, and parasites in clinical settings, it lacks efficacy against aerobic microorganisms. Due to its efficient molecular structure and synthetic usability due to the alcohol group in its framework, medicinal chemists aimed to reach new more effective molecules such as MTZ-hybrids. In this study, 2-[(benzimidazole/benzoxazole/benzothiazol-2-yl)thio]-N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]acetamide (5a-5j) derivatives were synthesized and their antimicrobial and antifungal effects on aerobic bacteria and Candida spp. were investigated. Notably, most of newly designed conjugates displayed higher potency than MTZ itself, especially

SUBMITTER: Akgun E 

PROVIDER: S-EPMC12150256 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature