Genetic background and multidomain interventions in mild cognitive impairment.

ABSTRACT:

Background

The growing prevalence of dementia emphasizes the need for effective prevention strategies. Although the partial efficacy of multidomain interventions for dementia prevention has been demonstrated, understanding the characteristics of individuals who benefit most from these interventions is crucial for optimizing resource allocation. This study investigated the association between participants' genetic backgrounds and the effectiveness of multidomain interventions for preventing dementia.

Methods

This study utilized data from the Japan-Multimodal Intervention Trial for the Prevention of Dementia (J-MINT), where older adults with mild cognitive impairment underwent 18 months of multidomain intervention. The intervention included exercise, nutrition, cognitive stimu

SUBMITTER: Fujita K 

PROVIDER: S-EPMC12150445 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature