Immunoinflammatory evidence of rheumatoid arthritis caused by COVID-19.

ABSTRACT:

Purpose

The relationship between coronavirus disease 2019 (COVID-19) and rheumatoid arthritis (RA) remains uncertain. We aimed to assess the association between COVID-19 and RA through immune inflammation.

Methods

First, we conducted a meta-analysis on the risk of COVID-19 infection, hospitalization rate, and mortality rate for patients with RA. Then, Mendelian randomization (MR) was used to evaluate the causal relationship between COVID-19 and RA, and further analyzed the cytokines and immune cells in COVID-19 and RA. Finally, we obtained microarray datasets of COVID-19, RA patients, and normal controls from the GEO database. And performed functional, pathway enrichment, and immune cell infiltration analysis on differentially expressed genes between each group.

Results</

SUBMITTER: Shao Z 

PROVIDER: S-EPMC12150480 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature