Enhancing the discriminatory power of polygenic scores for ADHD and autism in clinical and non-clinical samples.

ABSTRACT:

Background

Polygenic scores (PGS) are widely used in psychiatric genetic associations studies due to their predictive power for focal outcomes. However, they lack discriminatory power, in part due to the high degree of genetic overlap between psychiatric disorders. The lack of prediction specificity limits the clinical utility of psychiatric PGS, particularly for diagnostic applications. The goal of the study was to enhance the discriminatory power of psychiatric PGS for two highly comorbid and genetically correlated neurodevelopmental disorders in ADHD and autism spectrum disorder (ASD).

Methods

Genomic structural equation modeling (GenomicSEM) was used to generate novel PGS for ADHD and ASD by accounting for the genetic overlap between these disorders (and eight others) to

SUBMITTER: Li JJ 

PROVIDER: S-EPMC12150501 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature