Polycystic ovary syndrome and risk of pregnancy-induced hypertension, gestational diabetes mellitus, and preeclampsia: a Bayesian Mendelian randomization study.

ABSTRACT:

Background

Observational studies have shown an increased incidence of pregnancy complications in women with polycystic ovary syndrome (PCOS), but some controversy remains.

Objective

To investigate the causal association of polycystic ovary syndrome with pregnancy-induced hypertension (PIH), gestational diabetes mellitus (GDM), and preeclampsia (PEC) using two-sample Mendelian randomization (MR).

Methods

GWSA data from European populations were collected and causal analyses of PCOS (N = 113238) with PIH (N = 123579/118990), GDM (N = 123579/116363), and PEC (N = 123579/118291) were performed using mainly inverse variance weighted (IVW) method, along with Bayesian analysis to improve the accuracy of the results. Subsequently, heterogeneity, horizontal pleiotropy test and

SUBMITTER: Dang C 

PROVIDER: S-EPMC12150585 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature